Extended Data Figure 5 -.
Forest plot for association of the CHRNA3 locus and peripheral artery disease risk stratified by smoking status
When stratifying European MVP participants by smoking status (ever smokers vs. never smokers), nearly all the association signal resides within the ever smoker group. Previous reports of variation at the CHRNA3 locus demonstrate that carriers of the PAD risk allele have a reduced likelihood of cigarette smoking cessation1. This suggests that the PAD-CHRNA3 association is driven by a greater burden of tobacco exposure in those who carry the nicotine dependence/PAD risk allele. Logistic regression two-sided values of P are displayed.
Abbreviations: MVP, Million Veteran Program; PAD, Peripheral Artery Disease