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Sensitivity of EGFR variants to TKIs. Three derived cell lines, (A) L858R, (B) S768insVGH, and (C) P848L, were subjected to western blots to measure activated EGFR (via phospho‐EGFR Tyr992, p‐EGFR) and activated ERK (via phospho‐ERK Thr202/Tyr204, p‐ERK) after treating for 24 h with the indicated concentrations of erlotinib and osimertinib (nm). Total EGFR protein, ERK, and actin served as loading controls in all three independent experiments.
