Table 21.
Anti-inflammatory activity of the synthesized compounds
| Compounds | Edema inhibition (means ± E.M)a,b (%) | ||
|---|---|---|---|
| 1 h | 2 h | 3 h | |
| 94 | 42.3 ± 1.1 | 49.2 ± 1.2 | 57.1 ± 1.4 |
| 95 | 37.2 ± 1.3 | 46.3 ± 1.5 | 54.4 ± 1.1 |
| 96 | 34.5 ± 1.2 | 35.1 ± 1.5 | 48.2 ± 1.2 |
| 97 | 31.2 ± 1.2 | 35.1 ± 1.5 | 40.2 ± 1.6 |
| 98 | 39.1 ± 1.5 | 48.4 ± 1.2 | 55.6 ± 1.1 |
| Indomethacin | 44.7 ± 1.2 | 52.4 ± 1.2 | 61.2 ± 1.3 |
aDose 5 mg/kg b.m (p.o.)
b n = 6