Table 4.

Vandetanib cyano conjugates

Code	MS scan	Major fragments	tR (min)	Metabolic pathway	Postulated conjugate composition
VB486	486	389.4, 363.2	71.6	α Cyano addition and N-demethylation	V − CH3 + CN
VB500a	500a	373.2, 137.1	68.4	α Cyano addition	V + CN
VB500b	500b	456.9, 163.9	76	N-demethylation, α oxidation and α Cyano addition	V − CH3 + CN + O
VB502	502	484.3, 361.3, 287.4, 203.1	77.1	N-demethylation, α hydroxylation and α Cyano addition	V − CH3 + CN + OH