Table 7.
Top 20 perturbed KEGG signalling pathways implicated by genes in turquoise module.
| S. No. | Pathway | pERT | pG | Status |
|---|---|---|---|---|
| 1 | HIF-1 signalling pathway | 5.00E-06 | 6.60E-05 | Activated |
| 2 | Toll-like receptor signalling pathway | 0.001 | 0.007908 | Activated |
| 3 | cGMP-PKG signalling pathway | 0.009 | 0.051395 | Activated |
| 4 | NF-kappa B signalling pathway | 0.009 | 0.051395 | Activated |
| 5 | p53 signalling pathway | 0.009 | 0.051395 | Inhibited |
| 6 | AMPK signalling pathway | 0.015 | 0.077996 | Activated |
| 7 | Relaxin signalling pathway | 0.027 | 0.124522 | Activated |
| 8 | Estrogen signalling pathway | 0.037 | 0.158983 | Activated |
| 9 | NOD-like receptor signalling pathway | 0.038 | 0.162266 | Activated |
| 10 | Hippo signalling pathway | 0.043 | 0.178302 | Inhibited |
| 11 | AGE-RAGE signalling pathway in diabetic complications | 0.043 | 0.178302 | Activated |
| 12 | Apelin signalling pathway | 0.058 | 0.223144 | Activated |
| 13 | GnRH signalling pathway | 0.075 | 0.26927 | Activated |
| 14 | IL-17 signalling pathway | 0.077 | 0.274424 | Activated |
| 15 | Sphingolipid signalling pathway | 0.082 | 0.287085 | Activated |
| 16 | TGF-beta signalling pathway | 0.087 | 0.299441 | Inhibited |
| 17 | Phospholipase D signalling pathway | 0.088 | 0.301877 | Activated |
| 18 | mTOR signalling pathway | 0.091 | 0.309118 | Activated |
| 19 | Insulin signalling pathway | 0.091 | 0.309118 | Activated |
| 20 | Adipocytokine signalling pathway | 0.565 | 0.887575 | Activated |