Figure 1.

Cold acclimation reduces plasma FGF21 (A and B) and liver gene expression of Fgf21 (C). Age- and weight-matched animals were either kept at room temperature or cold exposed (4°C) for 7 days. Plasma samples were taken daily in the fed state. AUC = area under the curve. *p < 0.05 vs. Con. Unpaired, two-tailed t-test, n = 7 for the plasma data and n = 9 for the gene expression data.