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Cold exposure increases the expression of the FGF21 receptor Fgfr1 and the receptor co-factor β-klotho in both the Sc Ing (A) and the Epid (C) fat depots, but only enhances phosphorylation or ERK in the Sc Ing fat (B and D). Age- and weight-matched animals were either kept at room temperature or cold exposed (4°C) for 7 days. *p < 0.05 vs. Con. Unpaired, two-tailed t-test, n = 9.
