Figure 2.

MRI brain on day 1 and day 10 of hospital admission. DWI and FLAIR sequences are shown. DWI demonstrates cortical ribboning (signal hyperintensity of cerebral cortical gyri) of the regions. The corresponding FLAIR sequence shows less-intense cortical ribbon sign, however. Cortical ribboning is highly suggestive of sporadic CJD. There was no significant interval change in size or pattern of distribution from day 1 to day 10 hospital admission. No signal hyperintensity was found in putamen or caudate nucleus. CJD, Creutzfeldt-Jakob disease; DWI, diffusion-weighted imaging; FLAIR, fluid-attenuated inversion recovery