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. Author manuscript; available in PMC: 2019 Sep 30.
Published in final edited form as: Adv Pharmacol. 2009 Nov 27;57:253–289. doi: 10.1016/S1054-3589(08)57007-4

Figure 7:

Figure 7:

Effects of combinations of cocaine and JHW 007 at 10 min after injection on extracellular levels of DA. Panel A: Dose-dependent maximal effects of JHW 007 administered 10 min before compared with those of cocaine administered immediately before assessments. Ordinates: change in extracellular DA levels as a percentage of basal values before injection. Abscissae: dose of drug in mg/kg, log scale. Panel B: Observed effects of the combinations. Ordinates: change in extracellular DA levels as a percentage of basal values during the 30-min period after cocaine administration. Abscissae: dose of cocaine in mg/kg, log scale. Panel C: Observed effects compared with the predicted effects of the combinations. Ordinates and abscissae are as in Panel B. The calculated (predicted) additive dose-effect curve for cocaine in the presence of 3.0 (top) or 10.0 (bottom) mg/kg of JHW 007 is shown by the dashed straight line and the effects of cocaine alone are shown by the dotted line. The experimental (obtained) values are shown by the connected circles. Modified from Tanda et al. (2009).