Table 5.

Effect of time, gender, age, hydroxyurea use and opioid consumption one-hour prior and clinical pain score on mechanical pain threshold of foot

Variable	Estimate	SE	P value
Time (Acute pain vs Baseline)	−0.82	0.22	0.0017
Gender (Female vs Male)	0.01	0.40	0.98
Age	0.04	0.05	0.45
Hydroxyurea (Yes vs No)	−0.52	0.55	0.36
Opioid consumption (one-hour prior)	−0.003	0.05	0.95
Clinical Pain Score	−0.09	0.09	0.31

Data were log transformed to ensure fit

SE: standard error