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. 2019 Sep 30;14(9):e0222902. doi: 10.1371/journal.pone.0222902

Fig 5. Interactions of C3 pentyl analogue with the dopamine D3 receptor.

Fig 5

a) The C3 pentyl analogue (3e, purple) of (-)-stepholidine is observed to interact with Ser 192 of the receptor at the orthosteric binding site. In order for the C3 analogues to interact with Ser 192, the C10 hydroxyl group is placed in proximity of Ser 192; b) The 3e C3 analogue in another observed binding pose in which it interacts with Ser 196, rather than Ser 192. In this pose, ring D of the (-)-stepholidine core is bound deeper into the orthosteric binding site and the ligand is twisted causing Tyr 365 in the SBS to rotate and move away from Ser 182 of ECL2. The receptor is represented as a pink ribbon.