Fig 5. Letrozole removal resulted in fasting blood glucose levels and insulin tolerance similar to placebo mice.

Fasting blood glucose (A) and insulin levels (B) were measured for placebo and letrozole-treated mice before (Pre; week 5) and after (Post; week 12) pellet removal (n = 8 placebo, n = 8 letrozole). Removal of the letrozole pellet resulted in normalized fasting blood glucose levels and less elevation of insulin levels compared to before pellet removal. Student t-test was used, * p < 0.05. An insulin tolerance test (ITT) was performed on placebo and letrozole-treated mice after pellet removal (Post; week 12) (C) Removal of the letrozole pellet resulted in a lack of insulin resistance. A repeated measures ANOVA was used for comparing differences between placebo and letrozole mice over time, p < 0.05.