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. 2019 Sep 6;27(Suppl):S92–S103. doi: 10.1016/j.molmet.2019.06.014

Figure 3.

Figure 3

A model for autophagic clearance of pro-hIAPP oligomer. Pro-hIAPP dimer is formed in the membrane-rich fraction after binding of pro-hIAPP to the membrane fraction. Some pro-hIAPP dimers are translocated to the soluble fraction, while other pro-hIAPP dimers proceed to form pro-hIAPP timers. pro-hIAPP dimer and trimer are targets of autophagic clearance. high-n or fibrillary hIAPP oligomer could also be targets of autophagy. Autophagy enhancers may be able to expedite clearance of pro-hIAPP dimer, pro-trimer and hIAPP oligomer.