Skip to main content
. 2019 Sep 6;27(Suppl):S60–S68. doi: 10.1016/j.molmet.2019.06.012

Figure 2.

Figure 2

The three first responders of the UPR are diagrammed. Upon activation under ER stress, three sensors, IRE1α, PERK, and ATF6 send intracellular signals that allow the cell to either adapt or commit apoptosis.