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. 2019 Sep 6;27(Suppl):S147–S154. doi: 10.1016/j.molmet.2019.06.008

Figure 1.

Figure 1

Impact of HFD and age on metabolic parameters. Mice of the indicated strains were fed a regular chow (RC) or a high fat high sucrose diet (HFHS) for the indicated periods of time. They were then phenotyped as detailed in [14]. Boxplots show differences between HFHS (yellow) and RC (green) diet in the 6 mouse strains over time for (A) Body weight (g), (B) AUC glycemia measured during the glucose tolerance test (OGTT), (C) Basal insulinemia (ng/ml) measured at the start of the OGTT, and (D) Stimulated Insulinemia (ng/ml) measured at 15 min following glucose administration. Statistical significance between HFHS and RC at each time-point was measured using the two-sided Student's t-test and p-values were corrected for multiple comparisons using the Benjamini Hochberg FDR method. Statistically significant comparisons following FDR correction (FDR 0.05) are indicated by a double asterisk. Marginally significant comparisons (raw p-value 0.05) are indicated by a single asterisk. Figure reproduced from [14].