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. 2019 Sep 6;27(Suppl):S104–S113. doi: 10.1016/j.molmet.2019.06.013

Figure 2.

Figure 2

Ratios of unmethylated to total (unmethylated + methylated) INS DNA in the Diabetes Prevention Trial-1. The ratios of unmethylated:total INS DNA are shown over time in DPT-1 participants who did (progressors) or did not (non-progressors) develop T1D during the trial. (a) The time represents the years prior to the clinical diagnosis of T1D or the last study visit. Each line shows, with symbols, the measurements for an individual over time. (b) all of the data points from the progressors (n = 55) and non-progressors (n = 42) are shown. The levels were significantly higher in the progressors and non-progressors compared to healthy control subjects (***p < 0.001, ANOVA) but not to each other.