Relationship between measures of unmethylated INS DNA. (a,b) a comparison of the unmethylated:total (unmethylated + methylated) INS DNA detected with (a) the Exon2 or the transcription start site (TSS) probe or the (b) Exon 2 and IGRP probe are shown in patients who received islet autotransplants. In (a) all of the samples (127 pairs) over the first 3 days are shown (r = 0.66, p < 0.0001, Pearson) and (b) a subset (10 pairs) of the samples (r = 0.69, p = 0.027, Pearson) (c) The relationship between the Exon 2 (r = 0.34, p = 0.005, Pearson)and TSS probe and (d) the Exon 2 and IGRP probe (r = −.01, p = ns) in a subset of samples from DPT-1 participants (n = 66 pairs).