Table 2:

Analysis for association and predictors of SCD among PHIV with HF

Univariate analysis					† Multivariate analysis
	Hazard ratio	95% CI		p-value	Hazard ratio	95% CI		p-value
		Lower	Upper			Lower	Upper
Gender	1.223	0.821	1.843	0.28
Age	1.027	0.965	1.086	0.22
BMI	0.937	0.856	1.018	0.14
Diabetes	1.453	0.827	2.639	0.27
Hypertension	1.077	0.652	1.745	0.83
Hyperlipidemia	1.242	0.854	1.866	0.16
Smoking	1.162	0.825	1.724	0.37
H/o CAD	1.231	1.127	1.311	<0.001*	1.772	1.264	2.368	<0.001
Cocaine	1.372	1.185	1.516	<0.001*	1.571	1.223	2.113	0.002
LVEF	0.956	0.929	0.983	0.009*	0.803	0.727	0.985	0.017
PASP	1.035	0.986	1.164	0.09
SBP	1.122	0.632	1.868	0.53
DBP	1.138	0.588	1.726	0.50
HR	1.151	0.863	1.611	0.47
QRS duration	1.654	1.136	2.842	<0.001*	1.433	1.175	2.151	0.005
QTc duration	1.132	1.008	1.648	0.009*
SA	1.020	0.814	1.253	0.97
Viral load	1.211	1.123	1.492	<0.001*
CD4 count	0.983	0.969	0.991	<0.001*	0.907	0.861	0.997	0.004
ART duration	1.011	0.933	1.245	0.83
Beta blocker	0.754	0.622	0.944	<0.001*	0.535	0.341	0.773	0.002
ACE I/ARB	0.966	0.842	1.224	0.73
Spironolactone	1.114	0.883	1.463	0.81
Furosemide	1.231	0.655	2.453	0.56

^*p<0.05,

CAD= coronary artery disease, SA= sleep apnea, CAD= coronary artery disease, ICD= implantable cardioverter defibrillator, ACE I= angiotensin converting enzyme inhibitor, ARB= angiotensin receptor blocker, LVEF = left ventricular ejection fraction, PASP= pulmonary artery systolic pressure, BMI= body mass index.

^†Cox proportional hazard regression for multivariate analysis for primary outcome (sudden cardiac death) among PHIV with HF adjusting for confounding factors (such as (age, beta blocker use, CD4 count, cocaine use, and history of coronary artery disease), ECG parameters and left ventricular ejection fraction.