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. Author manuscript; available in PMC: 2020 Apr 1.
Published in final edited form as: Prog Polym Sci. 2019 Jan 17;91:126–140. doi: 10.1016/j.progpolymsci.2019.01.003

Fig. 2.

Fig. 2.

Illustration depicting the difference between actual defects observed in patient populations (top) compared to well-defined, induced defects used for in vivo studies (bottom). Common differences between actual injuries and defects used for research include shape, size, and orientation, and emphasize the clinical requirement of a hydrogel precursor solution that can be carefully molded and contoured to fit the defect site prior to crosslinking.