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. Author manuscript; available in PMC: 2020 Apr 1.
Published in final edited form as: Prog Polym Sci. 2019 Jan 17;91:126–140. doi: 10.1016/j.progpolymsci.2019.01.003

Table 1.

Summary of rheological properties of hydrogel precursor solutions. Dash marks (−) = data not provided.

Reference Hydrogel Type Materials Methods Shear Response Recovery Time Yield Stress (Pa)
Abbadessa et al. [114] Combinational Entanglement and Photoinitiated Methacrylated chondroitin sulfate and PEG triblock copolymer 20 mm cone and plate (1°), 27 μm gap Thinning < 10 s 19.2
Avery et al.[148] Physical Charge Gelatin and silicate nanoplatelets 25 mm cone and plate (1°) Thinning <1 min
Beck et al. [70] Chemical Photoinitiated Methacrylated hyaluronic acid and hyaluronic acid nanoparticles 20 mm parallel plate Thinning ~18 to 160
Beck et al. [38] Chemical Photoinitiated Methacrylated hyaluronic acid and hyaluronic acid nanoparticles 20 mm parallel plate, 500 μm gap Thinning <5 mins ~200 to 700
Beck et al.[2] Chemical Photoinitiated Methacrylated solubilized devitalized cartilage and devitalized cartilage microparticles 20 mm parallel plate, 500 μm gap Thinning ~30 to 1500
Beck et al. [67] Chemical Photoinitiated Methacrylated hyaluronic acid and devitalized/decellulariz ed cartilage microparticles 20 mm crosshatched parallel plate, 500 μm gap Thinning ~90 to 240
Dennis et al.[37] Physical Colloidal Flocculation Chondroitin sulfate or hyaluronic acid with hydroxyapatite nanoparticles 20 mm parallel plate, 500 μm gap Thinning <5 mins ~1 to 1400
Dennis et al.[76] Physical Colloidal Flocculation Hyaluronic acid, hydroxyapatite nanoparticles, and micronized tissue ECM 20 mm crosshatched parallel plate, 500 μm gap Thinning <5 mins ~100 to 1000
Dumas et al.[84] Chemical Reaction Lysine-derived polyurethane and bone particles 25 mm parallel plate, 1000 μm gap Thinning 2.1
Fakhari et al. [68] Physical Entanglement Hyaluronic acid nanoparticles 20 mm cone and plate (2°) Thinning ~500 to 2300
Gaharwar et al. [78] Physical Charge Gelatin and silicate nanoplatelets Static Tests: 25 mm Parallel Plate, 500 μm gap Transient Tests: 25 mm Cone and Plate (1°) Thinning <10 s 2 to 89
Geisler et al.[64] Physical Peptide Interactions Peptide (VKVKVKVKVKV-NH2) 25 mm parallel plate, 500 nm gap Thinning Immediate
Glassman et al.[65] Physical Peptide Interactions Protein-polymer triblock copolymer 25 mm sandblasted cone and plate (1°) Thinning ~9000
Hao et al.[77] Physical Entanglement Hydrophobically modified polyacrylamide and sodium oleate micelles 40 mm cone and plate (1°) <10 s
Li et al. [149] Chemical Reaction Glycol-chitosan and dibenzaldehyde-terminated polyethylene-glycol 20 mm parallel plate 40 to 84 min
Liu et al.[124] Chemical Reaction Catechol-modified PEG and Laponite Immediate
Montalbano et al.[150] Physical Entanglement Collagen and strontium glass particles 20 mm parallel plate, 500–1000 μm gap Thinning <100 s 2.18
Mouser et al.[112] Combinational Entanglement and Photoinitiated gelatin-methacryloyl and gellan gum 20 mm cone and plate (1°) Thinning 0.13 to 48.2
Olsen et al.[79] Physical Peptide Interactions Telechelic proteins with coiled-coil endblocks and flexible polyelectrolyte midblocks 25 mm cone and plate Thinning <10 s ~1400
Paxton et al.[111] Physical Entanglement (poloxamer) and Charge (alginate) Poloxamer 407, alginate, and alginate/gelatine 25 mm parallel plate, 500 μm gap Thinning <200 s 166 to 348
Ribeiro et al.[98] Physical Entanglement Poloxamer 407 and PEG 40 mm cone and plate (2°), 54 μm gap Thinning ~100 to 400
Rughani et al.[146] Combinational Peptide Interactions and Photoinitiated Self-assembling p-hairpin peptide incorporating non-natural sorbamide residues 25 mm parallel plate, 500 μm gap Thinning <2 h
Samaniuk et al.[48] - Mayonnaise 25.4 mm diameter, 150 mm long vane rheometer - - ~200
- Play-Doh - - ~3000
Townsend et al.[83] Physical Colloidal Flocculation Hyaluronic acid, hydroxyapatite nanoparticles, and micronized tissue ECM 20 mm crosshatched parallel plate, 500 μm gap Thinning ~100 to 550
Tsaryk et al.[69] Physical Entanglement Collagen and hyaluronic acid semi-interpenetrating network loaded with gelatin microspheres 15 mm crosshatched parallel plate, 1000 μm gap Thinning
Vulpe et al.[151] Chemical Reaction Collagen, hyaluronan, and sericin Concentric cylinder geometry Thinning
Wang et al.[26] Physical Charge Cationic and anionic gelatin nanospheres 20 mm parallel plate, 500 μm gap Thinning <1 min
Wilson et al.[108] Physical Entanglement and Charge Nanosilicates and kappa-cerrageenan 40 mm parallel plate, 200 μm gap Thinning <5 s 4.2 to 33
Yavvari et al.[145] Physical Charge Catechol-modified chitosan and Fe(III) 25 mm cone and plate (1°), 50 μm gap Immediate