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. 2019 Sep 6;27(Suppl):S25–S32. doi: 10.1016/j.molmet.2019.06.007

Figure 2.

Figure 2

Structure of commonly used targeted epigenome modifying systems. (A) A three zinc finger protein (green) in complex with DNA (gray). Inset shows one of the zinc finger modules and its binding to residues −1, 2, 3, and 6 (B) A TALE protein (blue) in complex with DNA (gray). Inset shows TALE repeat-variable di-residues (RVDs) labeled in red and corresponding DNA bases labeled in gray. (C) Nuclease-null dCas9 protein (purple) with designed sgRNA (orange) in complex with DNA (gray). Inset shows the interaction between the sgRNA and DNA. Reprinted with permission from Waryah and colleagues [49].