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. 2019 Sep 6;27(Suppl):S114–S121. doi: 10.1016/j.molmet.2019.06.025

Figure 3.

Figure 3

Suspected roles of the microbiota in the activation of MAIT cells and the onset of metabolic disease. At homeostasis, gut MAIT cells may promote the immune barrier function by producing IL-17 and IL-22. However, in dysbiosis situations observed in several metabolic diseases, gut barrier is compromised and MAIT cells in gut mucosa become pathogenic after activation by cytokines produced by DCs. This increases inflammation, as local and blood MAIT cells do in the affected organs. Adapted from [39], [45].