Figure 6.
Mild inflammatory response in neuron-specific Secisbp2R543Q mice. A and B, brain transcriptomic analysis reveals induction of immunity-related genes (red) on mRNA (A) and RPF levels (B). Selenoproteins are labeled in green and neuronal genes in blue. Only significant regulated genes are shown. n = 2 animals/genotype. *, q < 0.05, BH correction. C, pathway analysis shows that immunity-related pathways were induced on the transcriptional level. D, astrogliosis assessed by GFAP staining in the somatosensory cortex. E, Iba1 staining in the somatosensory cortex. Mean cell density was 375 and 378 cells/mm2 for control and CamK-RQ mice, respectively.