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. 2019 Sep 23;8:e48284. doi: 10.7554/eLife.48284

Figure 6. Blunted hypertrophy in HeyL-KO mice at 9 weeks after synergist ablation (SA).

(A) Experimental scheme for analyzing the influence of HeyL-KO (LKO) on overloaded plantaris muscle at 9 weeks after SA. (B) Normalized plantaris muscle weight [muscle weight/body weight (BW)] from sham (open circle) or SA (closed circle) muscle derived from Cont (light gray, n = 4) or LKO mice (blue, n = 10). *p<0.05. N.S.: not significant. (C) Immunostaining of laminin α2 (green) in sham or SA plantaris muscle derived from Cont or LKO mice. Scale bar: 50 μm. (D) Average myofiber cross-sectional area (CSA) values from sham (open circle) or SA (closed circle) plantaris muscle derived from Cont (light gray, n = 4) or LKO mice (blue, n = 10). *p<0.05. N.S.: not significant. Data represent the mean ± standard deviation. One-way ANOVA, followed by the Tukey–Kramer test, was used for statistical analyses.

Figure 6—source data 1. Numerical data for making the graphs in Figure 6.
Experiment number corresponds to all results.
elife-48284-fig6-data1.xlsx (36.6KB, xlsx)
DOI: 10.7554/eLife.48284.024

Figure 6.

Figure 6—figure supplement 1. Number of total myonuclei per 100 myofibers 9 weeks after SA.

Figure 6—figure supplement 1.

The number of total myonuclei per 100 myofibers from sham (open circle) or 9 weeks after SA (closed circle) (Cont: light gray, n = 4; LKO: blue, n = 10). The number of nuclei (DAPI) located beneath dystrophin staining was counted. *p<0.05.
Figure 6—figure supplement 1—source data 1. Numerical data for making the graph in Figure 6—figure supplement 1.
Experiment number corresponds to Figure 6—source data 1.
elife-48284-fig6-figsupp1-data1.xlsx (45.7KB, xlsx)
DOI: 10.7554/eLife.48284.023