TABLE 2. Binary matching variable:
Estimates of AUC (weighted and unweighted) comparing logistic regression regression (LR), conditional logistic regression (CLR) and proposed methods (Two-stage and Simultaneous). 95% confidence intervals (CI) for true AUC are based on the 2.5th and 97.5th percentiles of AUC estimates from 500 simulated datasets. Coverage probabilities are associated with 95% CIs obtained using proposed, bootstrap methods based on weighted AUC estimates. Results are averages of 500 simulated datasets, each of n = 200 matched case control pairs and where δ = 0.5
Model | γ | AUC | AC [95% CI] | Coverage Probability | |
---|---|---|---|---|---|
Unweighted | Weighted | ||||
LR | 0 | 0.64 | 0.64 [0.59 – 0.69] | 0.64 [0.59 – 0.69] | 0.99 |
CLR | 0 | 0.64 | 0.63 [0.59 – 0.69] | 0.64 [0.59 – 0.70] | 0.99 |
Two-stage | 0 | 0.64 | 0.63 [0.58 – 0.69] | 0.64 [0.59 – 0.70] | 0.99 |
Simultaneous | 0 | 0.64 | 0.63 [0.58 – 0.69] | 0.64 [0.59 – 0.70] | 0.99 |
LR | 0.25 | 0.65 | 0.64 [0.59 – 0.69] | 0.64 [0.58 – 0.69] | 0.95 |
CLR | 0.25 | 0.65 | 0.63 [0.58 – 0.69] | 0.65 [0.60 – 0.70] | 0.99 |
Two-stage | 0.25 | 0.65 | 0.62 [0.56 − 0.68] | 0.65 [0.60 – 0.71] | 0.99 |
Simultaneous | 0.25 | 0.65 | 0.62 [0.57 – 0.68] | 0.65 [0.60 – 0.70] | 0.99 |
LR | 0.50 | 0.67 | 0.64 [0.58 – 0.69] | 0.64 [0.58 – 0.69] | 0.80 |
CLR | 0.50 | 0.67 | 0.63 [0.58 – 0.68] | 0.65 [0.60 – 0.71] | 0.96 |
Two-stage | 0.50 | 0.67 | 0.61 [0.55 – 0.67] | 0.67 [0.62 – 0.72] | 0.99 |
Simultaneous | 0.50 | 0.67 | 0.61 [0.56 – 0.67] | 0.67 [0.62 – 0.72] | 0.99 |
LR | 0.75 | 0.69 | 0.64 [0.58 – 0.69] | 0.64 [0.58 – 0.69] | 0.53 |
CLR | 0.75 | 0.69 | 0.63 [0.58 – 0.69] | 0.66 [0.61 – 0.72] | 0.85 |
Two-stage | 0.75 | 0.69 | 0.60 [0.55 – 0.66] | 0.69 [0.65 – 0.73] | 0.99 |
Simultaneous | 0.75 | 0.69 | 0.60 [0.55 – 0.66] | 0.69 [0.65 – 0.73] | 0.99 |