Table 2.
Serum and CSF pNfH concentration
| Baseline Visit Only | All Available Visits (Baseline & Follow Up) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Control | At-risk | Converter b | Affected | Control | At-risk | Converter c | Affected | ||
| Serum pNfH: | Samples available: pNfH below LOD a: |
N=34 N=2 |
N=79 N=6 |
N=14 N=0 |
N=22 N=0 |
59 visits 3 visits |
224 visits 17 visits |
42 visits 2 visits |
68 visits 0 visit |
| Original scale (pg/ml) | Median (Range) |
22.9 (0.03-113.2) |
20.6 (1.2-212.7) |
12.7 (0.6-366.6) |
84.7 (2.0-1,156) |
25.7 (0.03-124.9) |
22.1 (0.03-212.7) |
43.4 (0.6-1,156) |
75.1 (1.1-1,156) |
| Log-transformed d | Mean ± SD (Range) |
2.9 ± 1.3 (0-4.7) |
3.0 ± 1.0 (0.8-5.4) |
2.8 ± 1.5 (0.4-5.9) |
4.2 ± 1.7 (1.1-7.1) |
3.1 ± 1.2 (0-4.8) |
2.9 ± 1.0 (0-5.4) |
3.9 ± 1.6 (0.4-7.1) |
4.2 ± 1.5 (0.7-7.1) |
| CSF pNfH: | Samples available e: | N=15 | N=46 | N=7 | N=9 | 21 visits | 116 visits | 20 visits | 23 visits |
| Original scale (pg/ml) | Median (Range) |
253 (24-1,321) |
252 (109-612) |
852 (109-3,900) |
1,657 (639-11,418) |
253 (24-1,321) |
278 (73.7-1,137) |
2,853 (109-12,244) |
1,782 (639-11,418) |
| Log-transformed d | Mean ± SD (Range) |
5.5 ± 0.9 (3.2-7.2) |
5.5 ± 0.4 (4.7-6.4) |
6.5 ± 1.2 (4.7-8.3) |
7.6 ± 0.9 (6.5-9.3) |
5.5 ± 0.8 (3.2-7.2) |
5.6 ± 0.5 (4.3-7.0) |
7.7 ± 1.3 (4.7-9.4) |
7.6 ± 0.8 (6.5-9.3) |
Baseline = first visit at which serum sample was available (with or without contemporaneous CSF collection)
N = number of participants. Visits = number of person-visits. LOD = limit of detection.
These observations were assigned the lowest detectable value in analyses and figures, but excluded from the calculation of summary statistics presented in this table.
All 14 converters were pre-symptomatic at baseline.
The 42 person-visits in the converter group included visits from when participants were pre-symptomatic and after phenoconversion.
Natural algorithm
None of the pNfH concentrations was below the limit of detection. N=11 participants (N=1 control, N=7 at-risk, N=3 converters) had CSF pNfH only at follow-up visits. Their data are included in the “All Available Visits” columns but not the “Baseline Visit Only” columns.