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. Author manuscript; available in PMC: 2020 Jan 4.
Published in final edited form as: Curr Cancer Drug Targets. 2019;19(10):838–851. doi: 10.2174/1568009619666190325144636

Figure 4. PCAIs induce apoptosis.

Figure 4.

A549 and H661 cells treated with PCAIs (1 – 10 μM) for 48 h were examined for externalization of phophatidylserine using Annexin V-FITC and flow cytometry. PCAI treatment promoted an increase in the number of cells with an increased Annexin V-FITC fluorescence prior to the loss of membrane integrity in early apoptosis (lower right-hand quadrant) and late apoptosis (upper right-hand quadrant). The dot plots (A) represent a single experiment while the graph (B) is an average from 3 independent experiments.