Table 2:
The effect of PCAIs on the viability of normal and lung cancer cells. The EC50 values were obtained from concentration-response curves from 48 h of exposure to varying concentrations of PCAIs.
| Cell line | EC50 at 48 h (μM) | ||||||
|---|---|---|---|---|---|---|---|
| NSL-BA-036 | NSL-BA-040 | NSL-BA-055 | NSL-BA-56 | Docetaxel | Paclitaxel | Erlotinib | |
| A549 | 8.9 | 5.2 | 5.6 | 49 | >200 | >200 | >200 |
| NCI-H1573 | 8.1 | 1.8 | 1.1 | 14 | >200 | >200 | >200 |
| NCI-H661 | 24 | 3.9 | 2.2 | 26 | >200 | 11 | >200 |
| NCI-H1975 | 10 | 3.6 | 5.4 | 8.3 | ND | ND | ND |
| NCI-H1299 | 5.4 | 5.5 | 5.2 | 12 | 72 | 60 | >200 |
| NCI-H460 | 11 | 4.6 | 6.2 | 26 | 56 | 26 | >200 |
| NCI-H1563 | 6.8 | 4.8 | 3.9 | 10 | 80 | >200 | >200 |
| WI-38 | 6.8 | 6.6 | 6.2 | 9.0 | ND | ND | ND |