Extended Data Figure 4. MiR-199a improves global heart function and decreases infarct mass one month after treatment.

a, Graphs showing percent changes in infarct mass, infarct mass over LV mass and EF, as indicated, between 2 and 28 days after MI and AAV6-Control or AAV6-miR-199a delivery, measured by cMRI. The number of analysed animals were 7 and 8, 7 and 8, 7 and 9 for infarct mass, infarct mass over LV mass and EF for the two groups, respectively. Upper panels: cumulative values for all pigs. Data are mean±SEM; *P<0.05; t-test, two tailed; lower panels: data from individual pigs. b, Infarct healing at one month after AAV6-miR-199a injection. The LGE-cMRI images (from apex to base, a to e) are the same as in Fig. 1h without red counterstain. The red arrow shows the infarcted area in the central plane. c, Gross anatomy of cardiac slices with corresponding LGE-cMRI images in representative AAV6-Control and AAV6-miR-199a treated pig hearts, at 28 days post-MI. d, Heart rate in sham and infarcted animals injected with AAV6-Control and AAV6-miR-199a at one month after treatment. Data are mean±SEM; the number of animals per group and time point are indicated.