Table 4.
Adjusted Regression Coefficientsa for the Cord-Mercury Concentration (ng/g) as a Predictor of Intelligence Quotient According to Selected Genotypes (Pilot, Extended, and Combined Groups), Avon Longitudinal Study of Parents and Children, United Kingdom, 1991–2000
| Gene | Log10(Hg), Pilot Sampleb | Log10(Hg), Extended Sample | Log10(Hg), Joint Sample | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No. | β | 95% CI | P for Interaction | No. | β | 95% CI | P for Interaction | No. | β | 95% CI | P for Interaction | |
| rs3811647 (TF) 11 | 402 | 4.8 | −2.8, 12.3 | 0.142 | 358 | 6.7 | −2.4, 15.8 | 0.288 | 760 | 6.2 | 0.4, 11.9 | 0.672 |
| rs3811647 (TF) 12 | 427 | 2.8 | −5.3, 10.9 | 341 | −4.7 | −14.1, 4.7 | 768 | 0.9 | −5.1, 7.0 | |||
| rs3811647 (TF) 22 | 104 | −7.1 | −24.5, 10.3 | 91 | 5.9 | −12.4, 24.2 | 195 | 0.9 | −11.3, 13.1 | |||
| rs662 (PON1) 11 | 494 | 7.5 | 0.5, 14.5 | 0.156 | 404 | 8.6 | −1.0, 18.2 | 0.117 | 898 | 7.8 | 2.2, 13.3 | 0.054 |
| rs662 (PON1) 12+22c | 439 | −2.3 | −10.0, 5.5 | 386 | −3.6 | −11.4, 4.3 | 825 | −2.2 | −7.7, 3.3 | |||
| rs1042838 (PGR) 11 | 648 | 6.7 | 0.4, 12.9 | 0.049 | 549 | 7.0 | −0.3, 14.3 | 0.004 | 1,197 | 7.0 | 2.3, 11.7 | 0.001 |
| rs1042838(PGR) 12+22c | 285 | −5.3 | −14.9, 4.3 | 241 | −11.8 | −23.0, −0.6 | 526 | −7.0 | −14.1, 0.0 | |||
| rs2049046 (BDNF) 11 | 274 | 8.2 | −1.9, 18.3 | 0.446 | 240 | 0.8 | −9.5, 11.1 | 0.653 | 514 | 4.8 | −2.3, 11.9 | 0.986 |
| rs2049046 (BDNF) 12 | 473 | 3.6 | −3.8, 10.9 | 381 | −0.1 | −9.7, 9.6 | 854 | 3.1 | −2.7, 8.9 | |||
| rs2049046 (BDNF) 22 | 186 | −6.2 | −17.7, 5.2 | 169 | 7.8 | −4.5, 20.1 | 355 | 1.4 | −6.7, 9.5 | |||
Abbreviations: BDNF, brain-derived neurotrophic factor; CI, confidence interval; Hg, mercury; PGR, progesterone receptor; PON1, paraoxonase 1; TF, transferrin.
a All multivariate linear regression models adjusted for sex, age, examiner, parental education level, maternal age, smoking during pregnancy, social class, parity, house ownership status, and estimated omega-3 intake (omega-3 intake estimated from seafood intake).
b Results from the pilot sample were slightly different from previous published results (8), due to adding more observations here but not due to adding a different confounding structure (data not shown).
c The alleles 12 and 22 were combined into a unique category due to low number of observations (22 alleles <10% of the total sample).