Table 5.
Adjusted Regression Coefficientsa for the Cord-Mercury Concentration (ng/g) as a Predictor of Total Intelligence Quotient According to Selected Genotypes, From a Joint Sample, Avon Longitudinal Study of Parents and Children, United Kingdom, 1991–2000
| Genotype | Log10(Cord-Slice Hg, ng/g) | |||
|---|---|---|---|---|
| No. | β | 95% CI | P for Interaction | |
| Cases with WISC-III IQ score available | 1,723 | |||
| New SNPs (discovery from joint sample analyses) | ||||
| rs5746136 (SOD2) 11 | 797 | 0.9 | −4.5, 6.3 | 0.082 |
| rs5746136 (SOD2) 12+22b | 926 | 5.5 | −0.2, 11.2 | |
| rs4149268 (ABCA1) 11 | 695 | −4.4 | −10.7, 1.8 | 0.049 |
| rs4149268 (ABCA1) 12 | 764 | 6.2 | 0.4, 12.0 | |
| rs4149268 (ABCA1) 22 | 264 | 9.2 | −1.6, 19.9 | |
| rs3890182 (ABCA1) 11 | 1,257 | 1.2 | −3.4, 5.8 | 0.038 |
| rs3890182 (ABCA1) 12+22b | 466 | 8.4 | 0.8, 16.1 | |
| rs2270836 (MT1M) 11 | 645 | −1.2 | −7.4, 5.1 | 0.054 |
| rs2270836 (MT1M) 12 | 777 | 5.1 | −0.8, 11.0 | |
| rs2270836 (MT1M) 22 | 281 | 10.3 | −0.1, 20.8 | |
Abbreviations: ABCA1, ATP binding cassette subfamily A member 1; CI, confidence interval; Hg, mercury; IQ, intelligence quotient; MT1M, metallothionein 1M; SOD2, superoxide dismutase 2; WISC-III, Wechsler Intelligence Scale for Children, Third Edition.
a All multivariable linear regression models adjusted for sex, age, examiner, parental education level, maternal age, smoking during pregnancy, social class, parity, house ownership status, and estimated omega-3 intake (omega-3 intake estimated from seafood intake).
b The alleles 12 and 22 were combined into a unique category due to low number of observations (22 alleles <10% of the total sample).