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. 2019 Sep 30;9:14020. doi: 10.1038/s41598-019-50160-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Inhibiting MAP4K4 slows migration in multiple glioma lines. The MAP4K4 inhibitor, PF06260933 dihydrochloride, slows migration in a wound healing. Scratch area (red) is marked at the specified time points in a representative monolayer of the identified cell lines: (A) U138, (B) LN18, (C) U87-MG, (D) T98G. For each cell line top row is representative control and bottom row is representative 1 μM drug treatment. (E) Quantification of normalized migration rate of each cell line calculated at 6–12 hours, n ≥ 4 for each concentration.