Fig. 4. Cerebellar white matter thickness is reduced in adult p75^NTR−/− mice.

a Hematoxylin and eosin staining of adult (6–9 months) p75^NTR+/+ and p75^NTR−/− cerebella. Boxed areas indicate the fields shown in b. I/II, III, IV, V, VI, VII, VIII, IX and X indicate the cerebellar folia. Scale bars, 500 µm. b High-magnification images of folium III of p75^NTR+/+ and p75^NTR−/− cerebella. Examples of WM and GL thickness are highlighted (white brackets). Dotted line delineates the GL/WM boundary. Scale bars, 150 µm. c, d Quantification of WM (c) and GL (d) thickness of the different cerebellar folia. The measurements were done at the base of each folia as shown by the white brackets in b. Ten cerebellar sections were quantified for each animal. Mean ± s.e.m of data from four p75^NTR+/+ and three p75^NTR−/− mice. *p < 0.05 compared to p75^NTR+/+ (unpaired Student’s t-test). Abbreviations: WM, white matter; GL, granule layer; ML, molecular layer