Table 2.
Standardized incidence ratios (SIRs) of second primary malignancies (SPMs) by latency period after the diagnosis of chronic lymphocytic leukemia (CLL), patient age, and race over time
| 1973–1982 O/E (95% CI) | 1983–1992 O/E (95% CI) | 1993–2002 O/E (95% CI) | 2003–2015 O/E (95% CI) | |
|---|---|---|---|---|
| Latency period | ||||
| 2–5 months | 1.61a (1.2–2.11) | 1.19 (0.9–1.54) | 1.54a (1.23–1.89) | 1.79a (1.52–2.08) |
| 6–11 months | 1.26 (0.96–1.64) | 1.04 (0.8–1.31) | 1.02 (0.81–1.26) | 1.44a (1.24–1.67) |
| 12–59 months | 1.30a (1.18–1.44) | 1.17a (1.08–1.28) | 1.14a (1.06–1.24) | 1.30a (1.22–1.39) |
| 60–119 months | 1.11 (0.99–1.25) | 1.07 (0.97–1.17) | 1.22a (1.13–1.32) | 1.34a (1.22–1.46) |
| ≥120 months | 1.08 (0.97–1.2) | 1.05 (0.96–1.15) | 1.18a (1.08–1.29) | 1.41a (1.07–1.82) |
| Patient age | ||||
| 15–49 years | 1.53a (1.17–1.97) | 1.31a (1.02–1.67) | 1.52a (1.21–1.87) | 2.14a (1.6–1.79) |
| 50–79 years | 1.18a (1.10–1.26) | 1.10a (1.04–1.16) | 1.19a (1.13–1.25) | 1.37a (1.3–1.44) |
| ≥80 years | 1.12 (0.93–1.34) | 1.02 (0.87–1.19) | 1.04 (0.9–1.2) | 1.26a (1.13–1.4) |
| Patient race | ||||
| White | 1.19a (1.12–1.26) | 1.08a (1.03–1.14) | 1.17a (1.12–1.23) | 1.36a (1.3–1.43) |
| Black | 1.27 (0.97–1.65) | 1.47a (1.18–1.81) | 1.49a (1.21–1.8) | 1.46a (1.21–1.75) |
| Others | 1.02 (0.33–2.38) | 1.62a (1.01–2.45) | 1.41 (0.99–1.95) | 2.07a (1.55–2.72) |
O/E observed/expected, CI confidence interval
aStatistically significant