Fig. 2. MiR-532-3p enhances p53-induced cell cycle arrest and apoptosis of CRC.

a Panther Pathway enrichment of significant altered genes in HT29-miR-532-3p cells and top ten pathways have been shown. b MiR-532-3p-induced activation of cell cycle arrest and apoptosis signaling in CRC cells. c Cell cycle analysis showed that miR-532-3p-induced cell cycle arrest in HT29 cells and miR-532-3p inhibitors could accelerate the transition in RKO cells. d Transfection of miR-532-3p mimics could induce apoptosis in HT29 after treatment with 5-Fluorouracil (5-Fu) or cisplatin. Further, miR-532-3p inhibitors could enhance apoptosis resistance in RKO cells. *p < 0.05, **p < 0.01, ***p < 0.001, n.s. non-significant