Fig. 6. MiR-532-3p restrains Wnt/β-catenin signaling via suppression of ETS1/TGM2 axis.

a MiR-532-3p-induced G0/G1 cell cycle arrest and ETS1 and TGM2 rescued the transition in HT29 cells. b ETS1 or TGM2 could rescue HT29-miR-532-3p cells from early apoptosis induced by 5-Fu and cisplatin. c Proliferation ability was determined with CCK-8 assay in HT29 cells; and ETS1 and TGM2 could elevate the cell growth by the suppression of miR-532-3p. d Western blot analysis of ETS1, TGM2, β-catenin, downstream molecules of β-catenin, and caspase proteins in HT29 cells after co-transfection with miR-532-3p mimics, ETS1, and TGM2 plasmids. *p < 0.05, n.s. non-significant