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. 2019 Sep 24;10:1007. doi: 10.3389/fphar.2019.01007

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Copyright © 2019 De Lucia, Pierannunzii, Pregnolato, Verduci, Crotti, Valcamonica, Pisoni, Comi, Lonati, Meroni and Murgo

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Time trend of VAS score over the course of follow-up (baseline and after 1, 6, 12, and 24 months) stratified by treatment (hyaluronic acid [HA] 1,500–3,200 kDa, hylan G-F 20, NSAIDS as controls [CTRLS]) and radiological grades II, III, and IV according to the Kellgren-Lawrence classification (A, K-L 2; B, K-L 3; C, K-L 4). Bars refer to standard error.