Figure 6.

Systemic pro-inflammatory cytokine secretion following murine fecal microbiota transplantation of C. jejuni infected mice harboring a human gut microbiota. Mice with a human gut microbiota were perorally infected with C. jejuni on day (d) 0 and d1 and subjected to murine fecal microbiota transplantation (mFMT) on d7, d8, and d9 post-infection (p.i.) or received vehicle (mock). On day 14 p.i., (A) TNF-α, (B) IL-12p70, and (C) IL-6 concentrations were measured in serum samples. Naive mice with a human gut microbiota served as uninfected and untreated controls. Box plots represent the 75th and 25th percentiles of medians (black bar inside the boxes). The total range, significance levels (p-values) determined by the one-sided ANOVA test with Tukey post-correction or by the Kruskal-Wallis test and Dunn's post-correction and the numbers of C. jejuni positive mice out of the total number of animals (in parentheses) are indicated. Data were pooled from four independent experiments.