| 1 Pregnancy loss |
4 |
|
Risk Ratio (M‐H, Random, 95% CI) |
Subtotals only |
| 1.1 Heparin (LMW) and aspirin versus aspirin alone |
1 |
98 |
Risk Ratio (M‐H, Random, 95% CI) |
0.78 [0.39, 1.57] |
| 1.2 Heparin (LMW) and aspirin versus IVIG |
1 |
40 |
Risk Ratio (M‐H, Random, 95% CI) |
0.37 [0.12, 1.16] |
| 1.3 Heparin (unfractionated) and aspirin versus aspirin |
2 |
140 |
Risk Ratio (M‐H, Random, 95% CI) |
0.46 [0.29, 0.71] |
| 2 Premature delivery |
4 |
|
Risk Ratio (M‐H, Random, 95% CI) |
Subtotals only |
| 2.1 Heparin (LMW) and aspirin versus aspirin alone |
1 |
98 |
Risk Ratio (M‐H, Random, 95% CI) |
0.46 [0.09, 2.40] |
| 2.2 Heparin (LMW) and aspirin versus IVIG |
1 |
40 |
Risk Ratio (M‐H, Random, 95% CI) |
3.3 [0.14, 76.46] |
| 2.3 Heparin (unfractionated) and aspirin versus aspirin |
2 |
140 |
Risk Ratio (M‐H, Random, 95% CI) |
2.18 [0.80, 5.93] |
| 3 Adverse pregnancy outcome (pregnancy loss or preterm labour) |
4 |
278 |
Risk Ratio (M‐H, Random, 95% CI) |
0.65 [0.49, 0.86] |
| 3.1 Heparin (LMW) and aspirin versus aspirin alone |
1 |
98 |
Risk Ratio (M‐H, Random, 95% CI) |
0.70 [0.39, 1.29] |
| 3.2 Heparin (LMW) and aspirin versus IVIG |
1 |
40 |
Risk Ratio (M‐H, Random, 95% CI) |
0.49 [0.18, 1.34] |
| 3.3 Heparin (unfractionated) and aspirin versus aspirin |
2 |
140 |
Risk Ratio (M‐H, Random, 95% CI) |
0.65 [0.47, 0.91] |
| 4 IUGR with interventions |
2 |
140 |
Risk Ratio (M‐H, Random, 95% CI) |
3.00 [0.63, 14.31] |
| 4.1 Heparin (LMW) and aspirin versus aspirin alone |
0 |
0 |
Risk Ratio (M‐H, Random, 95% CI) |
0.0 [0.0, 0.0] |
| 4.2 Heparin (LMW) and aspirin versus IVIG |
0 |
0 |
Risk Ratio (M‐H, Random, 95% CI) |
0.0 [0.0, 0.0] |
| 4.3 Heparin (unfractionated) and aspirin versus aspirin |
2 |
140 |
Risk Ratio (M‐H, Random, 95% CI) |
3.00 [0.63, 14.31] |
| 5 Adverse pregnancy outcome (pregnancy loss or IUGR) |
2 |
140 |
Risk Ratio (M‐H, Random, 95% CI) |
0.57 [0.39, 0.83] |
| 5.1 Heparin (LMW) and aspirin versus aspirin alone |
0 |
0 |
Risk Ratio (M‐H, Random, 95% CI) |
0.0 [0.0, 0.0] |
| 5.2 Heparin (LMW) and aspirin versus aspirin alone |
0 |
0 |
Risk Ratio (M‐H, Random, 95% CI) |
0.0 [0.0, 0.0] |
| 5.3 Heparin (unfractionated) and aspirin versus aspirin |
2 |
140 |
Risk Ratio (M‐H, Random, 95% CI) |
0.57 [0.39, 0.83] |
| 6 Neonatal intensive care admission |
1 |
40 |
Risk Ratio (M‐H, Random, 95% CI) |
0.37 [0.02, 8.50] |
| 6.1 Heparin (LMW) and aspirin versus aspirin alone |
0 |
0 |
Risk Ratio (M‐H, Random, 95% CI) |
0.0 [0.0, 0.0] |
| 6.2 Heparin (LMW) and aspirin versus IVIG |
1 |
40 |
Risk Ratio (M‐H, Random, 95% CI) |
0.37 [0.02, 8.50] |
| 6.3 Heparin (unfractionated) and aspirin versus aspirin |
0 |
0 |
Risk Ratio (M‐H, Random, 95% CI) |
0.0 [0.0, 0.0] |
| 7 Caesarean section |
2 |
|
Risk Ratio (M‐H, Random, 95% CI) |
Subtotals only |
| 7.1 Heparin (LMW) and aspirin versus aspirin alone |
0 |
0 |
Risk Ratio (M‐H, Random, 95% CI) |
0.0 [0.0, 0.0] |
| 7.2 Heparin (LMW) and aspirin versus IVIG |
1 |
40 |
Risk Ratio (M‐H, Random, 95% CI) |
0.37 [0.02, 8.50] |
| 7.3 Heparin (unfractionated) and aspirin versus aspirin |
1 |
50 |
Risk Ratio (M‐H, Random, 95% CI) |
2.0 [0.40, 9.95] |
| 8 Weighted mean difference for birthweight |
3 |
|
Mean Difference (IV, Random, 95% CI) |
Subtotals only |
| 8.1 Heparin (LMW) and aspirin versus aspirin alone |
1 |
98 |
Mean Difference (IV, Random, 95% CI) |
‐92.00 [‐379.00, 193.00] |
| 8.2 Heparin (LMW) and aspirin versus IVIG |
1 |
40 |
Mean Difference (IV, Random, 95% CI) |
52.0 [‐89.26, 193.26] |
| 8.3 Heparin (unfractionated) and aspirin versus aspirin |
1 |
50 |
Mean Difference (IV, Random, 95% CI) |
‐142.0 [‐515.33, 231.33] |
