Pattison 2000.

Methods	Single centre, fully blinded, placebo controlled RCT.
Participants	Inclusion criteria: 1) >/= 3 miscarriages. 2) +ve APL antibody either pre‐pregnancy or early in pregnancy determined by a IgG ACL > 5 GPL units or IgM ACL > 5 MPL units or presence of LA (APTT, dRVVT or KCT). Exclusion criteria: 1) History of thrombosis. 2) SLE. 3) Current or planned corticosteroids, NSAIDs, heparin or marine lipids.
Interventions	Aspirin 75 mg/day versus placebo.
Outcomes	Live birth, antenatal outcomes and neonatal outcomes.
Notes	20% subjects excluded from each treatment arm on the basis of ineligibility. Randomisation occured when pregnancy diagnosed if APL antibodies +ve before pregnancy or when detected during pregnancy. Aspirin/placebo commenced 50/44 days respectively after last menstrual period.
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	Unclear risk	B ‐ Unclear