Collignon‐Brach 1994.

Methods	RCT. Open label. Active controlled.
Participants	19 people with OHT or POAG (n=5). Racial constitution is not reported. Inclusion criteria: untreated IOP of at least 20 mmHg in at least one eye. Exclusion criteria: any other significant ocular pathology.
Interventions	Timolol 0.5& twice daily. Betaxolol 0.5% twice daily.
Outcomes	Change of visual field mean sensitivity. IOP.
Notes	4 years follow up. Drop‐out rate was 4 of 19 patients for both groups together, not specified for the groups separately. The authors state that there was no drop‐out due to drug‐related adverse events. Visual field data were averaged for both eyes of each patient.
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	Unclear risk	B ‐ Unclear