| Methods |
RCT.
Observer masked.
Multicenter. |
| Participants |
1636 participants with OHT.
25% African American.
Inclusion criteria: IOP between 24 and 32 mmHg in one eye and between 21 and 32 mmHg in the other eye, 2 normal and reliable visual fields, normal optic discs on stereophotographs.
Exclusion criteria: visual acuity below 20/40, previous ocular surgery (uncomplicated cataract surgery allowed), diabetic retinopathy. |
| Interventions |
Any topical medical antiglaucomatous treatment.
No treatment. |
| Outcomes |
Incidence of reproducible visual field defects or reproducible deterioration of optic discs attributable to POAG.
IOP. |
| Notes |
Median follow up 6 years.
173 drop‐outs (89 timolol group, 84 no treatment group). |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Allocation concealment? |
Low risk |
A ‐ Adequate |
