Wishart 1992.

Methods	RCT. Open label.
Participants	34 participants with OHT and open angles and 25 participants with OHT and narrow angles. Fellow‐eye served as control. Racial constitution is not reported. Inclusion criteria: IOP above 21 mmHg in both eyes, normal visual felds (Friedmann), normal optic discs. Exclusion criteria: history of anterior segment disease.
Interventions	Timolol 0.5% twice daily one eye. No treatment for the fellow eye.
Outcomes	Incidence of glaucomatous visual field defects or optic disc damage.
Notes	6 years follow‐up. Data of OHT with open angles and with narrow angles were analysed separately. Only the former are included in this review. No detailed information on dropouts is given.
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment?	Unclear risk	B ‐ Unclear

c/d ratio: cup to disk ratio 
 IOP: intraocular pressure 
 MD: mean defect 
 mmHG: millimetres mercury 
 OAG: open angle glaucoma 
 OHT: ocular hypertension 
 PDS: pigment dispersion syndrome 
 PEX: pseudoexfoliation 
 CLV: corrected loss variation 
 POAG: primary open angle glaucoma 
 RCT: randomised controlled trial 
 RNFL: retinal nerve fibre layer 
 SAP: standard automated perimetry