Lazzari 1983.

Methods	RandomizedDouble‐blindPlacebo‐controlledParallel‐groupDuration: 12 months
Participants	Country: Italy No. of centers: 40 Diagnosis: chronic senile cerebral insufficiency Diagnosis defined by: clinical examination Total no. of patients: 458 Age: Hydergine mean= 75.8 (SD=6.9), Placebo= 76.0 (SD=7.9) Gender: Hydergine: 73 males, 122 females, Placebo: 82 males, 111 females Inclusion: Scores > 2 on Sandoz Clinical Assessment Geriatric (SCAG) items (confusion, attention, short term memory, disorientation, anxiety, depression, emotional lability), Hachinski score between 5‐14. Exclusion: Severe hepatic, renal or cardiac disease, psychosis, alcoholism, pregancy, vascular accident, recent trauma that would affect stability, physical problems affecting testing (e.g., tremor, involuntary movements); psychotropic or CNS medications within 4 months of the study (e.g., antihypertensives, beta‐blockers).
Interventions	Route: not describedTreatment: Hydergine 1.5mg t.i.d.Control: Placebo t.i.d.
Outcomes	SCAG, Geriatric Rating Scales, Northwestern University Disability Scales, Nowlis test, Digit Symbol, Digit Span, Toulouse‐Pieron test
Notes	No. excluded after randomization and excluded from analysis: Total=184. Treatment=84, Control=100.