Rodriguez 1971.

Methods	RandomizedDouble‐blindPlacebo‐controlledParallel‐groupDuration: 12 weeks
Participants	Country: United StatesNo. of centers: 1Diagnosis: chronic cerebrovascular insufficiency associated with arteriosclerosisDiagnosis defined by: > 1 of the following (confusion, impairment of recent memory, impairment of mental alertness, deviations from normal mood)Total No. of patients: 60Age: Hydergine mean age was 71.9, range (62‐92), Placebo mean age was 73.0, range (62‐91)Sex: Hydergine: 15 female, 15 male, Placebo: 15 female, 15 maleInclusion: > 1 of the following (confusion, impairment of recent memory, impairment of mental alertness, deviations from normal mood)Exclusion: (1) psychosis, post‐traumatic brain damage, post infective brain disease, cerebral neoplasm, marked mental deterioration; (2) regular use of psychotropic drugs, sedatives, vasodilators; (3) physical conditions of such severity as to preclude participation; (4) unstable chronic physical illness; (4) instability in hospital setting; (5) expectation of discharge in < 12 weeks
Interventions	Route: sublingualTreatment: Hydergine 2, .5 mg tablets t.i.d.Control: Placebo 2, .5mg tablets t.i.d.
Outcomes	Sandoz Clinical Assessment Geriatric, Clinical Global Impression
Notes	No. excluded after randomization and not included in analyses: Total=1. Treatment=1, Control=0.