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. 2019 Sep 30;9:13990. doi: 10.1038/s41598-019-48238-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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MAP2 stained primary hippocampal neurons show effects of KLK8 knockdown for muscarinic agonist (mAChR-Ag) treatment. (A) Knockdown of KLK8 by siRNA drastically reduced dendrite length and arborization and inhibited dendritogenic potential of i-E mAChR-Ag replicated effects of i-E in dendrogenesis and dendrite outgrowth. Column charts represent (B) average number of dendrites or (C) dendrite length in each treatment group. Letters indicate statistical groups by FDR (p ≤ 0.05). Treatments sharing letter (within brain region) do not significantly differ.