| Methods |
Single centre. Open RCT. |
| Participants |
participants with acute UGI bleeding admitted to intensive care unit. |
| Interventions |
IV Pantoprazole 80mg bolus after randomisation and 40mg tid for 5 days. control group received no treatment until endoscopy and then treated with pantoprazole 40mg iv bolus followed by 40mg tid for 5 days. |
| Outcomes |
mortality, rebleeding, surgery, length of stay in ICU, mean number of blood units transfused and lesion stabilisation on repeat endoscopy at 5 days. No mention of follow up duration and time of outcome measurement. |
| Notes |
|
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Adequate sequence generation? |
Unclear risk |
Authors do not provide details of sequence generation. |
| Allocation concealment? |
Unclear risk |
Authors do not provide details of allocation concealment. |
| Blinding?
All outcomes |
Unclear risk |
Authors do not provide details of blinding. |
| Incomplete outcome data addressed?
All outcomes |
Unclear risk |
Abstract publication. Authors do not provide disposition of participants at each stage of study. Hence difficult to ascertain the robustness of assessment of incomplete data. The authors do not report withdrawal or dropout data. |
| Free of selective reporting? |
High risk |
Length of stay limited to the intensive care unit. No stigmata of recent haemorrhage per treatment group. |
| Free of other bias? |
High risk |
Included participants admitted to ICU only. Authors do not report indications for surgery, timing of endoscopy, time period for assessment of any of the outcomes including mortality. |
