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. 2006 Apr 19;2006(2):CD004200. doi: 10.1002/14651858.CD004200.pub4

Shepherd 1988.

Methods RCT
Participants Malignant obstruction of distal bile duct 
 Not suitable for curative surgery 
 Technically suitable for surgical bypass 
 78% had pancreatic cancer
Interventions Surgical bypass 
 10Fr polyethylene stent 
 Cephalosporins
Outcomes Technical success 
 Median duration of hospital stay for those alive > 30 days 
 Number of patients alive > 30 days 
 30‐day mortality 
 Procedural complications 
 Overall survival in days 
 Relief of jaundice 
 Number of re‐admissions 
 Total hospital stay
Notes N =52
Risk of bias
Bias Authors' judgement Support for judgement
Adequate sequence generation? Unclear risk Not described
Allocation concealment? Unclear risk Not described
Blinding? 
 All outcomes High risk  
Incomplete outcome data addressed? 
 All outcomes Low risk All described
Free of selective reporting? Low risk All outcomes described