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. 2019 Sep 24;10:1093. doi: 10.3389/fphar.2019.01093

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Copyright © 2019 Zhou, Shen and Lauschke

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Micropatterned co-cultures (MPCC) support phenotypic maintenance of primary human hepatocytes and hiPS-Heps. (A) MPCCs are established by seeding PHH or hiPS-Heps on micropatterned islands of ECM substrate, followed by seeding of supportive murine fibroblasts. Albumin and urea secretion as proxies for cell health can distinguish four hepatotoxins (B) from four nontoxic compounds (C) after 8 days of exposure in hiPS-Hep MPCC. Figure modified with permission from (Berger et al., 2015).