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. 2019 Sep 24;10:1093. doi: 10.3389/fphar.2019.01093

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Copyright © 2019 Zhou, Shen and Lauschke

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Hollow fiber bioreactors for organotypic hepatocyte culture. (A) Schematic representation of a hollow fiber bioreactor setup. Perfusion capillaries pass through a bioreactor module supplying the cells in the extracapillary space with oxygen and nutrients. (B) Hepatotoxicity of eight drugs was evaluated in bioreactors with hollow fibers made from polysulfone-g-poly(ethylene glycol) (PSf-g-PEG) or polysulfone (PSf) and was compared to cultures in cylindrical gels without hollow fibers. PSf-g-PEG fibers drastically reduced protein absorption and supported cellular functions as well as drug sensitivity. Error bars indicate ± SD; *p < 0.05, **p < 0.01, and ***p < 0.001. Figure modified with permission from (Shen et al., 2010; Williams et al., 2013).